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Longevity

Low-Dose Naltrexone

Low-Dose Naltrexone 1.5-4.5mg · Compounded · Schedule H

At 1/10th the addiction-treatment dose, low-dose naltrexone modulates the immune system and reduces inflammation. Shows promise across autoimmune conditions. The biohacker's immune hack.

₹999
/month
Includes: Doctor consultation · Prescription · Medication · Delivery
Have questions? Chat with us on WhatsApp
How your protocol works
1
Purchase
Secure checkout via Razorpay
2
Doctor calls
Licensed physician within 2hrs
3
Rx issued
Prescription after evaluation
4
Ships
Delivered within 48hrs
Dose Range
1.5–4.5mg
Type
Compounded
Schedule
Schedule H
Studies
200+
Pharmacology

How naltrexone LDN works

Low-dose naltrexone operates through three distinct mechanisms that make it fundamentally different from the high-dose addiction treatment formulation. The magic is in the dose: at 1.5-4.5mg, you get immune modulation without the opioid receptor blockade.

Transient Opioid Blockade
Brief blockade of opioid receptors triggers upregulation of endogenous endorphins and enkephalins, amplifying natural pain relief and mood regulation.
TLR4 Antagonism
Blocks toll-like receptor 4 on microglia, reducing neuroinflammation and dampening the pro-inflammatory cascade in autoimmune conditions.
OGF-OGFr Axis
Modulates the opioid growth factor pathway, regulating immune cell proliferation and promoting regulatory T cell expansion.
Evidence

Clinical data

Low-dose naltrexone has accumulated robust evidence across multiple autoimmune and pain conditions. The research base continues to grow as off-label longevity applications emerge.

200+
Published studies
Peer-reviewed literature on LDN
1.5–4.5mg
Optimal dose range
Clinical consensus (vs 50mg addiction dose)
6–12 wks
Time to effect
Typical immune response timeline
Protocol

How to get started

01
Book Consultation
Connect with a licensed physician via WhatsApp
02
Medical Evaluation
Doctor reviews your history and autoimmune profile
03
Prescription
If appropriate, compounded LDN prescription issued
04
Delivered
Custom compounded capsules shipped within 48 hours
FAQ

Common questions

What is LDN?
LDN stands for low-dose naltrexone. It's naltrexone prescribed at 1.5-4.5mg daily, a fraction of the 50mg addiction treatment dose. At this dose, it functions as an immune modulator rather than an opioid receptor antagonist.
How is it different from regular naltrexone?
Regular naltrexone (50mg) is used for opioid addiction treatment. At that dose, it fully blocks opioid receptors. LDN uses 1/10th the dose, causing only transient blockade that triggers endorphin upregulation and immune system modulation without addiction treatment effects.
What are the side effects?
LDN is generally well-tolerated. Most common mild side effects include vivid dreams (especially in first 1-2 weeks), mild sleep disturbance, or transient insomnia. These typically resolve. Serious adverse events are rare at these doses.
What conditions does LDN help?
Evidence exists for multiple sclerosis, Crohn's disease, fibromyalgia, and other autoimmune conditions. Growing research explores longevity and immune optimization use. Consult your physician to assess whether LDN is appropriate for your specific condition.
Is it available in India?
Yes. Naltrexone is a Schedule H drug in India, available with prescription. We compound LDN capsules at 1.5-4.5mg through licensed compounding pharmacies following your physician's prescription.
Get Started

Ready to optimize?

Book a consultation with a licensed physician to discuss whether LDN is appropriate for your immune health.

Have questions? Chat with us on WhatsApp