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Bremelanotide

Bremelanotide (PT-141) · MC4R Agonist · Specialist Supervised

Central-acting. Works on the brain, not blood flow. Melanocortin receptor agonist for when PDE5 inhibitors aren't enough or aren't appropriate. The peptide approach to desire.

₹3,499
/month
Includes: Specialist consultation · Prescription · Medication · Delivery
Have questions? Chat with us on WhatsApp
How your protocol works
1
Purchase
Secure checkout via Razorpay
2
Doctor calls
Licensed physician within 2hrs
3
Rx issued
Prescription after evaluation
4
Ships
Delivered within 48hrs
Route
Subcutaneous
Onset
45–60 min
Mechanism
CNS-acting
Class
Peptide
Pharmacology

How PT-141 works

PT-141 represents a fundamentally different approach to sexual function. Rather than targeting blood vessels, it activates desire circuits in the brain. It's the first melanocortin agonist approved for sexual dysfunction, opening new possibilities when traditional approaches aren't effective.

MC4R Agonism
Activates melanocortin-4 receptors in the hypothalamus—the brain's desire center. Works directly on sexual motivation and response circuits.
Central vs Peripheral
Unlike PDE5 inhibitors, PT-141 works on the nervous system, not vasculature. Addresses desire and arousal, not just mechanical function.
Gender-Neutral
Studied and effective in both male and female sexual dysfunction. Works across genders through the same neurological mechanism.
Evidence

Clinical data

PT-141 (bremelanotide, marketed as Vyleesi) was FDA-approved in 2019, marking a paradigm shift in sexual dysfunction treatment. It represents the first central-acting agent approved for this indication:

FDA 2019
Approval date (Vyleesi)
First-in-class CNS approach
PDE5-Resistant
Works when inhibitors don't
Efficacy in non-responders
Desire-Based
Acts on arousal & motivation
Mechanism of action
Protocol

How to get started

01
Specialist Consultation
Connect with a specialist via WhatsApp
02
Assessment
Specialist evaluates if PT-141 is appropriate
03
Prescription & Training
Prescription issued with injection instructions
04
Delivered
Pre-filled pens shipped within 48 hours
FAQ

Common questions

How is PT-141 different from Viagra?
Viagra (sildenafil) and Cialis (tadalafil) work on blood vessels in the penis. PT-141 works on your brain—specifically the hypothalamus, which controls sexual desire and arousal. It's useful when blood flow isn't the issue, or when PDE5 inhibitors haven't been effective. It works through an entirely different neurological pathway.
How is it administered?
PT-141 comes as a subcutaneous injection (under the skin), similar to an insulin pen. You self-inject a small dose (0.84mg) about 45 minutes before anticipated sexual activity. The injections are quick and use very fine needles. Your specialist will provide detailed training.
What are the side effects?
Common side effects include facial flushing, nausea, and headache. These are typically mild and transient. More serious side effects are rare but can include changes in blood pressure or skin darkening. Your specialist will discuss all risks and contraindications during consultation.
Who is this for?
PT-141 is ideal for those who haven't responded to PDE5 inhibitors, prefer a brain-based approach, or have medical conditions where blood vessel medications aren't appropriate. It's also studied in female sexual dysfunction and works across genders. Your specialist will determine if it's right for you.
Is PT-141 legal in India?
PT-141 (bremelanotide) is not currently approved by the Indian regulatory authority (DCGI) for domestic sale. However, it can be prescribed off-label by licensed physicians and imported for personal medical use. Through arq, a specialist will evaluate your case and discuss whether PT-141 is appropriate, including regulatory and import considerations specific to your situation.
Get Started

Ready to explore?

Book a specialist consultation to discuss whether PT-141 is the right approach for you.

Book Specialist Consultation on WhatsApp