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Longevity

Rapamycin 1mg

Sirolimus 1mg · Multiple manufacturers · Schedule H

The mTOR inhibitor that has anti-aging researchers paying very close attention. Originally an immunosuppressant, now studied for its remarkable effects on lifespan extension across every organism tested. The most promising longevity drug in clinical research.

₹4,999

/month

Doctor consultationFREE

Medication (30-day supply)₹4,999

Express deliveryFREE

Total₹4,999/mo

100% refund if not medically appropriate

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What happens after you purchase

You pay

Secure checkout via Razorpay

Doctor calls you

Free consultation within 2hrs

Prescription issued

If medically appropriate

Delivered

Delivered within 48hrs

Half-life

62 hours

Dosing Protocol

Weekly (low-dose)

Origin

Easter Island soil

Schedule

H (Rx)

Pharmacology

How rapamycin works

Rapamycin inhibits mTOR (mechanistic target of rapamycin), the master regulator of cellular growth. By suppressing mTORC1, rapamycin shifts cells from anabolic growth mode into catabolic maintenance and repair—the cellular state associated with longevity across species.

mTORC1 Inhibition

Selectively inhibits mTOR complex 1, the master growth regulator. Shifts cells from growth to maintenance/repair—the state associated with extended lifespan in model organisms.

Autophagy Induction

Upregulates cellular autophagy—the cleanup of damaged proteins and organelles. Enhanced autophagy removes senescent components and improves mitochondrial quality.

Senescent Cell Clearance

Emerging evidence suggests rapamycin reduces senescent cell burden—aged, dysfunctional cells that drive inflammation and age-related disease.

Pharmacokinetics

How your body processes it

Rapamycin (sirolimus) is poorly absorbed orally with highly variable bioavailability (~14%). It binds extensively to plasma proteins (92%) and distributes widely into tissues. The long half-life (62 hours) permits once-weekly dosing for longevity protocols. Critical: CYP3A4 interactions mean drug-drug interactions are common and require careful monitoring.

Bioavailability	~14% (oral) — highly variable
T_max (time to peak)	1–3 hours
Elimination half-life	62 hours (long!)
Steady state	5–7 days (multiple weekly doses reach plateau)
Volume of distribution	~100 L (widely distributed into tissues)
Protein binding	~92% — primarily FKBP12 binding essential for mechanism
Metabolism	Hepatic — CYP3A4 (primary) and P-glycoprotein substrate. Extensive first-pass metabolism.
Excretion	Fecal ~91% (biliary/fecal route). Minimal renal excretion.
Food effect	Consistent dosing schedule (with or without food) is critical. Variability in absorption compounds pharmacokinetic unpredictability.

Source: FDA-approved prescribing information (Rapamune), Kraig et al 2018 (PMID: 30482913)

Dosing

Optimal protocol

Longevity dosing differs radically from transplant dosing. Weekly pulsed dosing (3–6mg once weekly) targets intermittent mTOR inhibition to maximize lifespan benefits while minimizing chronic immunosuppression. Consistency matters—take every week on the same day at the same time.

Longevity Protocol: Pulsed Weekly Dosing

3–6mg once per week (NOT daily). Most biohackers use 5mg weekly. Take consistently on the same day and time (e.g., every Monday morning). This pulsed dosing intermittently inhibits mTOR, triggering autophagy and longevity pathways without chronic immunosuppression.

RECOMMENDED

With or Without Food

Rapamycin can be taken with or without food BUT must be consistent. Taking with food reduces absorption variability. Choose one approach and stick to it—do NOT alternate between fed and fasted states, as this increases pharmacokinetic unpredictability.

CONSISTENCY CRITICAL

DO NOT SKIP DOSES

Weekly pulsing is the cornerstone of longevity benefit. Missing a weekly dose disrupts mTOR oscillation patterns. Set a recurring alarm. If you miss a dose, skip it and resume on the next scheduled day—do NOT double-dose.

IMPORTANT

Lab Monitoring

Baseline labs before starting: lipid panel, glucose, renal function (creatinine, BUN), CBC. Follow-up labs at 4–6 weeks, then every 3–6 months. Some users experience elevated triglycerides (10%) or glucose (8%)—usually mild and reversible with dose adjustment or dietary changes.

ESSENTIAL

Evidence

Published research

Rapamycin is the most-studied longevity intervention in biology. Lifespan extension data spans yeast, worms, flies, fish, mice, and primate studies. In humans, immune function improvement and safety data from decades of transplant use support its use at much lower longevity doses.

2014 Aging Cell PMID: 25540326

Rapamycin improves immune response in aging humans

Mannick et al. demonstrated that 12 weeks of low-dose rapamycin (0.5mg weekly) improved vaccine response in elderly individuals, increasing influenza antibody titers by ~20%. Suggests that intermittent mTOR inhibition can enhance adaptive immunity.

RANDOMIZED CONTROLLED TRIAL

2018 GeroScience PMID: 30482913

Intermittent rapamycin dosing for longevity safety assessment

Kraig et al. reviewed safety data from intermittent rapamycin protocols. Weekly pulsed dosing (5–6mg) was well-tolerated with minimal adverse effects compared to daily dosing. Longer follow-up needed, but intermittent mTOR inhibition appears safe and potentially synergistic with aging biology.

SAFETY REVIEW

2009 Nature PMID: 19718033

Late-life rapamycin treatment extends lifespan in mice

Harrison et al. (NIA Intervention Testing Program) showed that rapamycin given starting at 600 days (old age in mice) increased lifespan by 9–14% in both sexes. Demonstrated that longevity benefits persist even when started late in life, relevant to human aging interventions.

LIFESPAN EXTENSION — 9–14%

2020 Cell Reports PMID: 33188759

Rapamycin extends healthspan in aging primates

Pifferi et al. demonstrated that rapamycin improved survival and reduced cancer incidence in aging primates. While lifespan extension in primates is not yet fully established, healthspan improvements (disease resistance, immune function) are documented.

PRIMATE AGING MODEL

Safety

Side effects & safety

At longevity doses (3–6mg weekly), side effects are minimal compared to transplant dosing (5+ mg daily). However, rapamycin does require monitoring. Effects below are incidence rates at weekly longevity dosing from clinical observations and trial data.

Mouth Sores / Aphthous Ulcers

15%

Elevated Triglycerides

10%

Glucose Elevation

Delayed Wound Healing

Headache / Fatigue

Critical: Weekly vs Daily Dosing

Longevity doses (3–6mg weekly) are MUCH safer than transplant doses (5+ mg daily). Immunosuppression at weekly dosing is minimal and may even improve certain immune responses. However, rapamycin ALWAYS increases infection risk slightly—avoid live vaccines, inform all healthcare providers, and seek medical attention for signs of infection. Contraindicated in patients with active infections, untreated TB, or severe immunodeficiency.

Interactions

Drug interactions

Rapamycin is a strong CYP3A4 substrate and a P-glycoprotein substrate. Interactions are COMMON and can be dangerous. Any CYP3A4 inhibitor or inducer dramatically changes rapamycin levels. Your physician MUST review your full medication list. Live vaccines are contraindicated.

Grapefruit Juice / Grapefruit

CYP3A4 inhibitor—DOUBLES rapamycin blood levels. Can achieve transplant-level exposure from longevity dosing. ABSOLUTE CONTRAINDICATION: Avoid grapefruit entirely while taking rapamycin. Pomegranate juice may have similar effects.

Mechanism: CYP3A4 inhibition → dramatically increased bioavailability

Antifungals (Ketoconazole, Itraconazole)

Strong CYP3A4 inhibitors. Increase rapamycin levels 3–10x. Requires therapeutic drug monitoring and significant dose reduction. Generally avoid if possible; if necessary, coordinate closely with your physician.

Mechanism: CYP3A4 inhibition → severe elevation of rapamycin

Antibiotics (Erythromycin, Clarithromycin)

CYP3A4 inhibitors—increase rapamycin levels. Azithromycin may be safer if antibiotic is needed. Always inform your prescribing physician that you are on rapamycin before starting any antibiotic.

Mechanism: CYP3A4 inhibition

Rifampin

CYP3A4 inducer—DECREASES rapamycin by 82%. If TB treatment is needed, rapamycin dosing may need to increase dramatically or discontinue temporarily during TB therapy.

Mechanism: CYP3A4 induction → severe reduction of rapamycin

Calcineurin Inhibitors (Cyclosporine, Tacrolimus)

ABSOLUTE CONTRAINDICATION in combination use outside of transplant settings. Both cause immunosuppression and together increase risk of infection and nephrotoxicity dramatically. DO NOT combine for longevity use.

Mechanism: Synergistic immunosuppression and nephrotoxicity

Live Vaccines

ABSOLUTE CONTRAINDICATION. Rapamycin suppresses immune response enough to prevent live vaccine efficacy and increase risk of vaccine-strain infection. Inactivated vaccines (flu shot, COVID-19) are acceptable. Stop rapamycin before any live vaccine.

Mechanism: Immunosuppression

FAQ

Common questions

Is rapamycin safe for longevity use?

Rapamycin has decades of safety data from organ transplant patients taking much higher doses. For longevity use, dosing is dramatically lower (1mg weekly vs. 5+ mg daily). Side effects at low dose are minimal. Physician oversight and baseline labs are essential.

What is mTOR?

mTOR (mechanistic target of rapamycin) is a master cellular regulator that controls growth, protein synthesis, and metabolic rate. It's central to aging: constantly active mTOR drives growth at the expense of maintenance. Inhibiting mTOR shifts the cell-survival calculus toward longevity.

What dosing protocol is recommended?

Most longevity researchers use 1mg once per week. Some use 5mg weekly. Dosing varies by individual. Your physician will determine the optimal dose based on your baseline, goals, and tolerance. Labs (lipid panel, glucose, renal function) should be monitored.

Side effects at low dose?

At longevity doses (1mg/week), rapamycin is well-tolerated. Minor effects include mouth sores, elevated cholesterol, and glucose changes—mostly reversible. Immunosuppression is dose-dependent; at low dose, immune function may actually improve. Regular monitoring essential.

Is it available in India?

Yes. Rapamycin (Sirolimus) is a Schedule H drug in India, available under brand names like Rapamune and generics. It's manufactured domestically at a fraction of US costs. Available via arq with physician consultation and valid prescription.

What's included in the ₹4,999/month protocol price?

The monthly protocol price includes the doctor consultation with baseline health and lab review, prescription issuance after medical evaluation, rapamycin medication (typically 1-5mg weekly based on your protocol), and delivery to your door within 48 hours. No hidden fees—what you see is what you pay. Regular monitoring labs are coordinated separately.